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Part Used : เมล็ดActivity : HEPATOTOXIC ACTIVITYSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For liver tumors, No nodular lesions, such as HCC and adenomas, were observed in the liver during this study. Treatment with and corn oil alone significantly decreased the numbers and/or areas of GST-P positive foci, putative preneoplastic lesions of the liver, compared with the control group. However, additional treatment with indomethacin tended to abolish the decrease in GST-P positive foci.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : น้ำมันจากเมล็ดActivity : HEPATOTOXIC ACTIVITYSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 15% corn oil + 6% protein* (Group 1) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : PositiveRemark : Result: glutathione (GSH) level was significantly lower in only group fed 15% corn oil with 6 g/100 g protein among acetaminophen-treated groups, activities of Glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) were significantly elevated in all groups except the one fed beef tallow with 20 g/100 g protein, suggesting low protein might exacerbate drug-induced hepatotoxicity.Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
Part Used : น้ำมันจากเมล็ดActivity : HEPATOTOXIC ACTIVITYSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 15% corn oil + 20% protein* (Group 2) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : PositiveRemark : Result: Activities of Glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) were significantly elevated in all groups except the one fed beef tallow with 20 g/100 g protein, suggesting low protein might exacerbate drug-induced hepatotoxicity.Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
Part Used : น้ำมันจากเมล็ดActivity : HEPATOTOXIC ACTIVITYSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 14% beef tallow + 1% corn oil + 6% protein* (Group 3) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : PositiveRemark : Result: Activities of Glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) were significantly elevated in all groups except the one fed beef tallow with 20 g/100 g protein, suggesting low protein might exacerbate drug-induced hepatotoxicity.Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
Part Used : น้ำมันจากเมล็ดActivity : HEPATOTOXIC ACTIVITYSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 14% beef tallow + 1% corn oil + 20% protein* (Group 4) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : EquivocalRemark :Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
