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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : maize polyamine oxidase (MPAO)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 5 daysType of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : Etoposide 0 - 100 microMResult : PositiveRemark : Result: Recombinant maize polyamine oxidase (MPAO) expression in the 4.31 MPAOnuc-MCF7 cells conferred higher growth sensitivity to 24 h treatment with etoposide, a widely used antineoplastic drug which inhibits topoisomerase II at the strand rejoining step resulting in single and double strand breaks in DNA. Data from a dose-response analysis have indeed showed that the -Dox MPAOnuc-MCF7 cells are characterised by an IC50 value (etoposide concentration at which 50% inhibition of cell growth is observed) for etoposide of 22.9+/-0.5 microM which is significantly lower than that of the +Dox MPAOnuc-MCF7 cells (IC50 = 42.0+/- 0.3 microM) (P<0.05).
Part Used : ไม่ระบุActivity : CELL PROLIFERATION INHIBITIONSolvent/Active Compound : maize polyamine oxidase (MPAO)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 5 daysType of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : Etoposide 0 - 100 microMResult : PositiveRemark : Result: Recombinant maize polyamine oxidase (MPAO) expression in the 4.31 MPAOnuc-MCF7 cells conferred higher growth sensitivity to 24 h treatment with etoposide, a widely used antineoplastic drug which inhibits topoisomerase II at the strand rejoining step resulting in single and double strand breaks in DNA. Data from a dose-response analysis have indeed showed that the -Dox MPAOnuc-MCF7 cells are characterised by an IC50 value (etoposide concentration at which 50% inhibition of cell growth is observed) for etoposide of 22.9+/-0.5 microM which is significantly lower than that of the +Dox MPAOnuc-MCF7 cells (IC50 = 42.0+/- 0.3 microM) (P<0.05).
