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Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : n-6 linoleinc acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : EquivocalRemark : Result: The serum PGE2 levels tended to decrease on treatment wih indomethacin (IM) but were increased by corn oil compared with the control level. These latter increases tended to be diminished to the control level with the addition of IM (Corn oil +IM). However, no significant differences were observed between the values.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : PROSTAGLANDIN E2 INHIBITIONSolvent/Active Compound : n-6 linoleinc acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : EquivocalRemark : Result: The serum PGE2 levels tended to decrease on treatment wih indomethacin (IM) but were increased by corn oil compared with the control level. These latter increases tended to be diminished to the control level with the addition of IM (Corn oil +IM). However, no significant differences were observed between the values.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : GASTROINTESTINAL EFFECTS (UNSPECIFIED)Solvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For colon tumor, the multiplicity of adenomas was significantly decreased in the indomethacin + corn oil group compared with the corn oil alone group.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : CARCINOGENESIS INHIBITIONSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For colon tumor, the multiplicity of adenomas was significantly decreased in the indomethacin + corn oil group compared with the corn oil alone group.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : ANTITUMOR ACTIVITYSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For colon tumor, the multiplicity of adenomas was significantly decreased in the indomethacin + corn oil group compared with the corn oil alone group.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : ANTITUMOR ACTIVITYSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : EquivocalRemark : Result: For lung tumors, a tendency for increase in lung tumor formation was also observed in the corn oil group, but reduction to the control level was evident with additional indomethacin treatment.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : RESPIRATORY EFFECTS (UNSPECIFIED)Solvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : EquivocalRemark : Result: For lung tumors, a tendency for increase in lung tumor formation was also observed in the corn oil group, but reduction to the control level was evident with additional indomethacin treatment.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : CARCINOGENESIS INHIBITIONSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : EquivocalRemark : Result: For lung tumors, a tendency for increase in lung tumor formation was also observed in the corn oil group, but reduction to the control level was evident with additional indomethacin treatment.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : TUMOR PROMOTING EFFECTSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For renal cell tumors, corn oil with indomethacin significantly increased the incidence of nephroblastomas.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : เมล็ดActivity : NEPHROTOXIC ACTIVITYSolvent/Active Compound : n-6 linoleic acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : PositiveRemark : Result: For renal cell tumors, corn oil with indomethacin significantly increased the incidence of nephroblastomas.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
