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Part Used : รากActivity : CYCLOOXYGENASE 2 INHIBITIONSolvent/Active Compound : Curcumin (Cur)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : curcumin 0-20 micromolarDuration : -Type of interaction : PharmacodynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 0-40 micromolarResult : PositiveRemark :Note : Result: A synergistic effect was observed in inhibition of cell growth when the cells were exposed to various concentrations of celecoxib combined with curcumin. The inhibitory effect of the combination on cell growth was associated with an increased induction of apoptosis. The synergistic effect was mediated through a mechanism that involves inhibition of COX-2 activity. Data incomplete
Part Used : เหง้าActivity : CYCLOOXYGENASE 2 INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : -Result : PositiveRemark : The level of COX-2 protein expression was reduced almost 6-fold after combination treatment. The results demonstrate synergism between curcumim and 5-FU at higher doses against the human colon cancer cell line HT-29 which associated with the decreased expression of COX-2 protein.
