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Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : CurcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : LosartanDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Rats were gavaged with losartan 10 mg/kg after repeat oral dose of curcumin 100 mg/kg for 7 days. Result: Rats prior exposure to curcumin had significantly increased in AUC0-t and Cmax of the oral losartan. Administration of 10 mg/kg losartan in the treatment group resulted in a marked increase in the AUC0-t and Cmax from 2080+/-837 to 3460+/-1350 micrograms/L. h and 475+/-63.1 to 1660+/-892 micrograms/L, respectively. An approximate 1.7-fold increace of the AUC0-t and 3.5-fold increase of the Cmax in treatment group.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : CurcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : LosartanDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Rats were gavaged with losartan 10 mg/kg after repeat oral dose of curcumin 100 mg/kg for 7 days. Result: The AUC0-t and Cmax of losartan metabolite EXP3174 of treatment group were significantly increased from 766+/-416 to 1460+/-818 micrograms/L. h and 108+/-61.1 to 341+/-187 micrograms/L, respectively. Tmax of EXP3174 of the control group was nonsignificantly 78% higher than that of group pre-treated with curcumin (3.33+/-2.34 to 1.88+/-0.64 h).
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg for turmeric juiceDuration : Single administrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The AUC values of tacrolimus in the rat pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. These AUC values were almost equal to the values for those pre-treated with 100% pomelo juice.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 31 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : -Result : NegativeRemark : There was no significant difference in diclofenac bioavailability parameters when the NSAID was given alone or combined with curcumin.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Curcumin-475 mg capsuleType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 8N(Treatment) : 8Sex : -Age : 32 - 38 yrs.Route : Oral administrationDose/Conc.(herb) : curcumin-475mg capsules/dayDuration : Following the administration of Daonil-5 mg, blood samples (1 mL) were collected from the patients at 0.5, 1, 2, 3, 4, 6, 8, 12 and 24h. Patients were treated with curcumin-475mg capsules for the next 10 consecutive days, one capsule per day. During treatment period, patients received both curcumin and Daonil. On the 11th day of the study following the administration of curcumin along with Daonil 5 mg, blood samples (1 mL) were collected once again at 0.5, 1, 2, 3, 4, 6, 8, 12 and 24 h.Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Daonil*/Glyburide/Glibenclamide/Diadeta/Glybenclamide/GlybenzcyclamideDose/Conc.(drug) : -Result : PositiveRemark : Result: Glyburide concentrations changed at the second hour, Cmax was unchanged, the glucose levels were decreased, Area Under first Movement Curre (AUMC) was increased significantly, and no patient has experienced the hypoglycaemia. The co-administration of curcumin capsules with glyburide may be beneficial to the patients in better glycaemic control.Note : Subject total: Subjects were type-2 diabetic patients.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : curcuminoidsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kg of body weightDuration : -Type of interaction : PharmacokineticsInteraction with drug : Sulfamethazine*/Sulfadimidine/Sulfadimethyldiazine/SulfamezathineDose/Conc.(drug) : -Result : PositiveRemark : Results: Curcuminoids at 5 mg/kg were able to enhance significantly the absorption rate and peak concentration of sulfamethazine in blood (p<0.05), while those at 10 mg/kg were not. A decrease in clearance and an increase in AUC of the sulfonamide also occurred at the low dose of curcuminoids (p<0.05). At 10 mg/kg, curcuminoids also inhibited the clearance of sulfamazathine which resulted in a significant increase of AUC (p<0.05), but not the elimination half-life of the drug.Note : The animals obtained curcuminoids 5 and 10 mg/kg of body weight orally, one hour prior to an injection of sulfamethazine (50 mg/kg of body weight) i.p. Blood sample (0.2-0.3 mL) were subsequently withdrawn from the tail vein at various time intervals and collected into heparinized tubes.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : curcuminoidsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kg of body weightDuration : -Type of interaction : PharmacokineticsInteraction with drug : Sulfamethazine*/Sulfadimidine/Sulfadimethyldiazine/SulfamezathineDose/Conc.(drug) : -Result : PositiveRemark : Results: Curcuminoids at 5 mg/kg were able to enhance significantly the absorption rate and peak concentration of sulfamethazine in blood (p<0.05), while those at 10 mg/kg were not. A decrease in clearance and an increase in AUC of the sulfonamide also occurred at the low dose of curcuminoids (p<0.05). At 10 mg/kg, curcuminoids also inhibited the clearance of sulfamazathine which resulted in a significant increase of AUC (p<0.05), but not the elimination half-life of the drug.Note : The animals obtained curcuminoids 5 and 10 mg/kg of body weight orally, one hour prior to an injection of sulfamethazine (50 mg/kg of body weight) i.p. Blood sample (0.2-0.3 mL) were subsequently withdrawn from the tail vein at various time intervals and collected into heparinized tubes.
