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Part Used : ไม่ระบุActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : CurcuminType of experiment : -Type of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Curcumin inhibits P-gp, but has very poor oral bioavailability. Caution in patients taking high doses with anticoagulants or antiplatelet drugs.Note : Data incomplete, data from review article.
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : hydroethanolicType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25-50 micrograms/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Both Curcuma longa and Curcuma sp. "Khamin-oi" extracts increased the amount of R123 accumulation in both wild-type and vinblastine-selected Caco-2 calls in a concentration-dependent manner.
Part Used : ไม่ระบุActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : curcuminType of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : None known. Curcumin inhibits P-gp, but has very poor oral bioavailability. Caution in patients taking high doses with anticoagulants or antiplatelet drugs.Note : Data from review, data incomplete.
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : -Result : PositiveRemark : Curcumin inhibited P-gp-mediated efflux of rhodamine 123 and enhanced cytotoxicity of vinblastine at short time exposure (1-2 h).Note : Data from review
Part Used : -Activity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Extract of Curcuma longaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 microgram/ml of Curcuma longa in pH 7.4 phosphate buffer solution with 4% DMSODuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: The extract of Curcuma longa had inhibitory effect on the transepithelial transport of Rho-123 in Caco-2 cell.Note : Data incomplete
Part Used : -Activity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Extract of Curcuma longaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 microgram/ml of extract of Curcuma longa in pH 7.4 phosphate buffer solution with 4% DMSODuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: The extract of Curcuma longa could inhibit Rho-123 transport from serosal to mucosal surfaces of everted rat ileum with comparable inhibitory potential.Note : Data incomplete
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : curcuminnoids (curcumin I, II, III)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Human cervical arcinoma cell line (KB-V1). Results: Treating the cells with non-toxic dose of curcuminnoids increased their sensitivity to vinblastine only in the P-gp expressing drug resistant cell line KB-V1; and curcumin I retained the drug in KB-V1 cells more effectively than curcumin II and III, repectively.
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : CurcuminoidsType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Caco-2 cell monolayers. Results: curcuminoids and an extract of Psidium guajava showed the highest inhibitory effect on P-glycoprotein mediated efflux of Rho-123 in Caco-2 cells.
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : curcuminoidsType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: rat ileum Results: curcuminoids and Psidium guajava could inhibit the efflux mechanism of P-glycoprotein in the rat ileum.
Part Used : ไม่ระบุActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactionsNote : Data incomplete
