Synonym |
Thai / English name |
Part Used : รากActivity : CYP2D6 INHIBITIONSolvent/Active Compound : Aqueous extractsType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Resut: Percent inhibition = 48.6+/-6.42
Part Used : เหง้าActivity : CYP2D6 INHIBITIONSolvent/Active Compound : CurcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Curcumin inhibited CYP1A2 (IC50, 40.0 micromolar), CYP3A4 (IL50, 16.3 micromolar), CYP2D6 (IC50, 50.3 micromolar), CYP2C9 (IL50, 4.3 micromolar) and CYP2B6 (IC50, 24.5 micromolar)
Part Used : เหง้าActivity : CYP2D6 INHIBITIONSolvent/Active Compound : aqueousType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The aqueous extract of Cucuma longa inhibited CYP2D6 activity with IC50 value 163.3+/-41.6 and 430.0+/-43.6 microgram/ml for big and small rhizome, respectively.Note : Testosterone 6beta-hydroxylase and dextromethorphan O-demethylase were used as maker of CYP3A4 and CYP2D6 activity, respectively.