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ZINGIBERACEAE Curcuma longa L.

Synonym

ZINGIBERACEAE Curcuma domestica Valeton

Thai / English name

ขมิ้น*

[1-3] of 3 article(s) found

หน้า 1

[1] IN VITRO INHIBITION OF HUMAN CYTOCHROME P450-MEDIATED METABOLISM OF MARKER SUBSTRATES BY NATURAL PRODUCTS.
FOSTER BC,VANDENHOEK S,HANA J,ET AL.
PHYTOMEDICINE 2003 Vol.10(),334-42 $11159 [Full]

Part Used : ราก
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Aqueous extracts

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 82.3+/-6.05

[2] EFFECTS OF MACE AND NUTMEG ON HUMAN CYTOCHROME P450 3A4 AND 2C9 ACTIVITY.
KIMURA Y,ITO H,HATANO T
BIOL PHARM BULL 2010 Vol.33(12),1977-82 $33078 [Full]

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : IC50=14.8 microgram/ml

[3] INHIBITION OF HUMAN RECOMBINANT CYTOCHROME P450S BY CURCUMIN AND CURCUMIN DECOMPOSITION PRODUCTS.
APPIAH-OPONG R,COMMANDEUR JNM,VAN VUGT-LUSSENBURG B,ET AL.
TOXICOLOGY 2007 Vol.235(1-2),83-91 402961 [Abstract]

Part Used : เหง้า
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Curcumin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Curcumin inhibited CYP1A2 (IC50, 40.0 micromolar), CYP3A4 (IL50, 16.3 micromolar), CYP2D6 (IC50, 50.3 micromolar), CYP2C9 (IL50, 4.3 micromolar) and CYP2B6 (IC50, 24.5 micromolar)

หน้า 1

EN

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