Part Used : เหง้า
Activity : CELL CYCLE CYTOTOXICITY(G2 + M PHASE)
Solvent/Active Compound : curcumin
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Intraperitoneal
Dose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.
Duration : 22 days
Type of interaction : Pharmacodynamics
Interaction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHP
Dose/Conc.(drug) : -
Remark : Result: Curcumin combined with oxaliplatin treatment induced apoptosis, accompanied by ultrastructural changes and cell cycle arrest in S and G2/M phases.
Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.