ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เหง้า

Activity : CARCINOGENESIS INHIBITION

Solvent/Active Compound : curcumin

Type of experiment : in vivo

Type of animal : mouse

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Intraperitoneal

Dose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.

Duration : 22 days

Type of interaction : Pharmacodynamics

Interaction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHP

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.

Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.

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