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Part Used : เหง้าActivity : APOPTOSIS INDUCTIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: Curcumin combined with oxaliplatin treatment induced apoptosis, accompanied by ultrastructural changes and cell cycle arrest in S and G2/M phases.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : รากActivity : APOPTOSIS INDUCTIONSolvent/Active Compound : Curcumin (Cur)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : curcumin 0-20 micromolarDuration : -Type of interaction : PharmacodynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 0-40 micromolarResult : PositiveRemark :Note : Result: A synergistic effect was observed in inhibition of cell growth when the cells were exposed to various concentrations of celecoxib combined with curcumin. The inhibitory effect of the combination on cell growth was associated with an increased induction of apoptosis. The synergistic effect was mediated through a mechanism that involves inhibition of COX-2 activity. Data incomplete
