Part Used : เหง้า
Activity : CASPASE-3 STIMULATION
Solvent/Active Compound : curcumin
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Intraperitoneal
Dose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.
Duration : 22 days
Type of interaction : Pharmacodynamics
Interaction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHP
Dose/Conc.(drug) : -
Remark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.
Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.