Part Used : เหง้า
Activity : ANALGESIC ACTIVITY
Solvent/Active Compound : curcumin
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : curcumin 60 mg/kg
Duration : 4 weeks
Type of interaction : Pharmacodynamics
Interaction with drug : Insulin
Dose/Conc.(drug) : -
Note : Result: Chronic treatment with insulin (10 IU/kg/day, s.c.) and its combinations with curcumin (60 mg/kg, p.o.) for 4 weeks starting from the 4th week of STZ injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.