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Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : CurcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : LosartanDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Rats were gavaged with losartan 10 mg/kg after repeat oral dose of curcumin 100 mg/kg for 7 days. Result: Rats prior exposure to curcumin had significantly increased in AUC0-t and Cmax of the oral losartan. Administration of 10 mg/kg losartan in the treatment group resulted in a marked increase in the AUC0-t and Cmax from 2080+/-837 to 3460+/-1350 micrograms/L. h and 475+/-63.1 to 1660+/-892 micrograms/L, respectively. An approximate 1.7-fold increace of the AUC0-t and 3.5-fold increase of the Cmax in treatment group.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : CurcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : LosartanDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Rats were gavaged with losartan 10 mg/kg after repeat oral dose of curcumin 100 mg/kg for 7 days. Result: Rats prior exposure to curcumin had significantly increased in AUC0-t and Cmax of the oral losartan. Administration of 10 mg/kg losartan in the treatment group resulted in a marked increase in the AUC0-t and Cmax from 2080+/-837 to 3460+/-1350 micrograms/L. h and 475+/-63.1 to 1660+/-892 micrograms/L, respectively. An approximate 1.7-fold increace of the AUC0-t and 3.5-fold increase of the Cmax in treatment group.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : CurcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : LosartanDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Rats were gavaged with losartan 10 mg/kg after repeat oral dose of curcumin 100 mg/kg for 7 days. Result: The AUC0-t and Cmax of losartan metabolite EXP3174 of treatment group were significantly increased from 766+/-416 to 1460+/-818 micrograms/L. h and 108+/-61.1 to 341+/-187 micrograms/L, respectively. Tmax of EXP3174 of the control group was nonsignificantly 78% higher than that of group pre-treated with curcumin (3.33+/-2.34 to 1.88+/-0.64 h).
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : CurcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : LosartanDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Rats were gavaged with losartan 10 mg/kg after repeat oral dose of curcumin 100 mg/kg for 7 days. Result: The AUC0-t and Cmax of losartan metabolite EXP3174 of treatment group were significantly increased from 766+/-416 to 1460+/-818 micrograms/L. h and 108+/-61.1 to 341+/-187 micrograms/L, respectively. Tmax of EXP3174 of the control group was nonsignificantly 78% higher than that of group pre-treated with curcumin (3.33+/-2.34 to 1.88+/-0.64 h).
