| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : CELL GROWTH INHIBITION EFFECTSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: Combinatorial administration of curcumin and oxaliplatin evidently inhibited the growth of colorectal cancer in nude mice, which was significantly more effective than either agent alone.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : APOPTOSIS INDUCTIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: Curcumin combined with oxaliplatin treatment induced apoptosis, accompanied by ultrastructural changes and cell cycle arrest in S and G2/M phases.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : CELL CYCLE CYTOTOXICITY(S PHASE)Solvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: Curcumin combined with oxaliplatin treatment induced apoptosis, accompanied by ultrastructural changes and cell cycle arrest in S and G2/M phases.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : CELL CYCLE CYTOTOXICITY(G2 + M PHASE)Solvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: Curcumin combined with oxaliplatin treatment induced apoptosis, accompanied by ultrastructural changes and cell cycle arrest in S and G2/M phases.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : PROTEIN EXPRESSION STIMULATIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : POLY (ADP-RIBOSE) POLYMERASE STIMULATIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : CASPASE-3 STIMULATIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : PROTEIN EXPRESSION INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : HEAT SHOCK PROTEIN SUPPRESSIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
Part Used : เหง้าActivity : CARCINOGENESIS INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Intraperitoneal combinatorial curcumin (50 mg/kg) and oxaliplatin (25 mg/kg), thrice per week.Duration : 22 daysType of interaction : PharmacodynamicsInteraction with drug : Oxaliplatin*/Diaminocyclohexane oxalatoplatinum/L-OHPDose/Conc.(drug) : -Result : PositiveRemark : Result: While the number of apoptotic tumor cells and the expression of Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased significantly, the expression of Bcl-2, survivin, HSP70, pro-caspase-3, and pro-PARP were dramatically suppressed in tumor cells after the treatment with combinatorial curcumin and oxaliplatin for 22 days.Note : Administration of combined curcumin and oxaliplatin effectively suppressed colorectal carcinoma in vivo through inducing apoptosis and thus may provide an effective treatment for colorectal carcinoma.
