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ZINGIBERACEAE Curcuma longa L.

Synonym

ZINGIBERACEAE Curcuma domestica Valeton

Thai / English name

ขมิ้น*

[1-2] of 2 article(s) found

หน้า 1

[1] ENHANCING ACTIVITY OF ANTICANCER DRUGS IN MULTIDRUG RESISTANT TUMORS BY MODULATING P-GLYCOPROTEIN THROUGH DIETARY NUTRACEUTICALS.
MUHAMMAD KHAN,AMARA MARYAM,TAHIR MEHMOOD,ET AL.
ASIAN PAC J CANCER PREV 2015 Vol.16(16),6831-9 $59875 [Full]

Part Used : เหง้า
Activity : DRUG INTERACTION

Solvent/Active Compound : curcumin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Vinblastine*/VLB
Dose/Conc.(drug) : -

Result : Positive

Remark : Curcumin inhibited P-gp-mediated efflux of rhodamine 123 and enhanced cytotoxicity of vinblastine at short time exposure (1-2 h).

Note : Data from review

Part Used : เหง้า
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : curcumin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Vinblastine*/VLB
Dose/Conc.(drug) : -

Result : Positive

Remark : Curcumin inhibited P-gp-mediated efflux of rhodamine 123 and enhanced cytotoxicity of vinblastine at short time exposure (1-2 h).

Note : Data from review

[2] BIOCHEMICAL MECHANISM OF MODULATION OF ABC TRANSPORTERS: P-GLYCLOPROTEIN (P-GP, ABCB1), MULTIDRUG RESISTANCE PROTEIN 1 (MRP1, ABCC1) AND MITOXANTRONE RESISTANCE PROTEIN (MXR, ABCG2) BY CURCUMINOIDS
CHEARWAE W
CHIANG MAI : CHIANG MAI UNIVERSITY, (สำนักงานคณะกรรมการวิจัยแห่งชาติ) 2005 Vol.(),211p 278646 [Abstract]

Part Used : เหง้า
Activity : DRUG INTERACTION

Solvent/Active Compound : curcuminnoids (curcumin I, II, III)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Vinblastine*/VLB
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: Human cervical arcinoma cell line (KB-V1). Results: Treating the cells with non-toxic dose of curcuminnoids increased their sensitivity to vinblastine only in the P-gp expressing drug resistant cell line KB-V1; and curcumin I retained the drug in KB-V1 cells more effectively than curcumin II and III, repectively.

Part Used : เหง้า
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : curcuminnoids (curcumin I, II, III)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Vinblastine*/VLB
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: Human cervical arcinoma cell line (KB-V1). Results: Treating the cells with non-toxic dose of curcuminnoids increased their sensitivity to vinblastine only in the P-gp expressing drug resistant cell line KB-V1; and curcumin I retained the drug in KB-V1 cells more effectively than curcumin II and III, repectively.

หน้า 1

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