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Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 125-250 microgram/ml, MICDuration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : NorfloxacinDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Standard broth microdilution. The time kill curves showed that a combined curcumin and oxacillin treatment reduced the bacterial counts below the lowest detectable limit after 24 h. This study suggested that curcumin reduced the minimal inhibitory concentration (MIC) of several antibiotics tested, notably of oxacillin, ampicillin, ciprofloxacin and norfloxacin, and that curcumin in combination with antibiotics could lead to the development of new combination of antibiotics against Methicillin-resistant Stapphylococcus aureus (MRSA) infection.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Intra-muscularDose/Conc.(herb) : 20 mg kg-1 body wt.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : NorfloxacinDose/Conc.(drug) : -Result : NegativeRemark :Note : Curcumin significantly (p<0.05) enhanced the effect of morphine on the visceral pain responses, however did not reverse the effect of naloxone. - Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Intra-muscularDose/Conc.(herb) : 40 mg kg-1 body wt.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : NorfloxacinDose/Conc.(drug) : -Result : NegativeRemark :Note : Curcumin significantly (p<0.05) enhanced the effect of morphine on the visceral pain responses, however did not reverse the effect of naloxone. - Data incomplete.
