Synonym |
Thai / English name |
Part Used : เหง้าActivity : NOCICEPTIVE RESPONSE REDUCTIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : curcumin 60 mg/kgDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: Chronic treatment with insulin (10 IU/kg/day, s.c.) and its combinations with curcumin (60 mg/kg, p.o.) for 4 weeks starting from the 4th week of STZ injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : curcumin 60 mg/kgDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: Chronic treatment with insulin (10 IU/kg/day, s.c.) and its combinations with curcumin (60 mg/kg, p.o.) for 4 weeks starting from the 4th week of STZ injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : curcumin 60 mg/kgDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: Chronic treatment with insulin (10 IU/kg/day, s.c.) and its combinations with curcumin (60 mg/kg, p.o.) for 4 weeks starting from the 4th week of STZ injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.
Part Used : เหง้าActivity : TUMOR NECROSING FACTOR SECRETION INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : curcumin 60 mg/kgDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: Chronic treatment with insulin (10 IU/kg/day, s.c.) and its combinations with curcumin (60 mg/kg, p.o.) for 4 weeks starting from the 4th week of STZ injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.
Part Used : เหง้าActivity : NITRIC OXIDE SYNTHESIS INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : curcumin 60 mg/kgDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: Chronic treatment with insulin (10 IU/kg/day, s.c.) and its combinations with curcumin (60 mg/kg, p.o.) for 4 weeks starting from the 4th week of STZ injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.
Part Used : เหง้าActivity : DIABETIC NEUROPATHY IMPROVEMENTSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : curcumin 60 mg/kgDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: Chronic treatment with insulin (10 IU/kg/day, s.c.) and its combinations with curcumin (60 mg/kg, p.o.) for 4 weeks starting from the 4th week of STZ injection significantly attenuated thermal hyperalgesia and the hot-plate latencies. There was a significant inhibition of TNF-alpha and NO levels when these drugs were given in combination compared with their effects per se.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : curcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : Type of study = C2C12 (mouse myoblast cell line)Note : There can be a synergistic interaction between curcumin and insulin in glucose metabolism-associated cell signaling, such as AMPK/ACC, Pl3-kinase/Akt and GLUT4 pathways.