Synonym |
Thai / English name |
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 1Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : -Result : PositiveRemark : ขมิ้นชันมีฤทธิ์ยับยั้งเอนไซม์ CYP3A4, CYP1A4 ทำให้ยาที่เมตาบอไลซ์ผ่านเอนไซม์เหล่านี้ถูกแปรสภาพลดลง ทำให้ระดับยาในเลือดสูงขึ้นNote : Data incomplete, data from review article
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 1Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : -Result : PositiveRemark : ขมิ้นชันมีฤทธิ์ยับยั้งเอนไซม์ CYP3A4, CYP1A4 ทำให้ยาที่เมตาบอไลซ์ผ่านเอนไซม์เหล่านี้ถูกแปรสภาพลดลง ทำให้ระดับยาในเลือดสูงขึ้นNote : Data incomplete, data from review article
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 31 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : -Result : PositiveRemark : The interaction between diclofenac (10 mg/kg) and curcumin (31 mg/kg) that mediates the antinociceptive effect was synergistic.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : curcuminType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 31 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : -Result : NegativeRemark : There was no significant difference in diclofenac bioavailability parameters when the NSAID was given alone or combined with curcumin.