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COMPOSITAE (ASTERACEAE) Atractylodes lancea (Thunb.) DC.

Synonym

none ...

Thai / English name

โกฐเขมา*

[1-2] of 2 article(s) found

หน้า 1

[1] HERB-DRUG INTERACTION OF 50 CHINESE HERBAL MEDICINES ON CYP3A4 ACTIVITY IN VITRO AND IN VIVO.
LI-HENG PAO,OLIVER YOA-PU HU,HSIEN-YUAN FAN,ET AL.
AM J CHIN MED 2012 Vol.40(1),57-73 $39467 [Full]

Part Used : เหง้า
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 2-6 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : The effect of the single Chinese herbal preparation on CYP3A4 activity in human liver microsome in 3 different concentrations, 2 mg/ml 4 mg/ml and 6 mg/ml.

[2] INHIBITORY ACTIVITIES OF THAI MEDICINAL PLANTS WITH PROMISING ACTIVITIES AGAINST MALARIA AND CHOLANGIOCARCINOMA ON HUMAN CYTOCHROME P450.
WIRIYAPORN SUMSAKUL,WIRATCHANEE MAHAVORASIRIKUL,KESARA NA-BANGCHANG
PHYTOTHER RES 2015 Vol.29(),1926-33 $60695 [Full]

Part Used : เหง้า
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : ethanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : The selective inhibitor ketoconazole showed the most potent inhibitory activity on CYP3A4 with mean IC50 of 0.23 microgram/mL. PC, DM, DL, PI were most potent with mean IC 1.54-6.43 microgram/mL. PC exhibited similar inhibitory activity to ketoconazole (p > 0.05). GM and ZO exhibitied moderate potencies (mean IC50 11.33 and 11.58 microgram/mL, respectively). MF and AL exhibited relatively low potencies (mean IC50 41.91 and 54.36 microgram/mL, respectively) (substrate: nifedipine)

Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).

หน้า 1

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