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COMPOSITAE (ASTERACEAE) Atractylodes lancea (Thunb.) DC.

Synonym

none ...

Thai / English name

โกฐเขมา*

[1-2] of 2 article(s) found

หน้า 1

[1] INHIBITORY ACTIVITIES OF THAI MEDICINAL PLANTS WITH PROMISING ACTIVITIES AGAINST MALARIA AND CHOLANGIOCARCINOMA ON HUMAN CYTOCHROME P450.
WIRIYAPORN SUMSAKUL,WIRATCHANEE MAHAVORASIRIKUL,KESARA NA-BANGCHANG
PHYTOTHER RES 2015 Vol.29(),1926-33 $60695 [Full]

Part Used : เหง้า
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : ethanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : The selective inhibitor of CYP1A2 alpha-naphthoflavone exhibited the most potent inhibitory activity on enzyme activity with mean IC50 of 0.01 microgram/mL. PC and AL exhibited most potent activity with IC50 values in a similar range of that of the alpha-naphthoflavone (p > 0.05). DM, DL, GM and ZO exhibited moderate potencies (IC50 1.04-9.87 microgram/mL), whereas PI and MF exhibited relatively low potencies (IC50 12.95 and 22.05 microgram/mL, respectively) (Substrate=phenacetin)

Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).

[2] INHIBITION OF HUMAN CYP1A2 ACTIVITY BY THAI MEDICINAL PLANTS WITH PROMISING ACTIVITIES AGAINST CHOLANGIOCARCINOMA.
WIRATCHANEE MAHAVORASIRIKUL,WIRIYAPORN SOOMSAKUL,VITHOON VIYANANT,ET AL.
THAI J PHARMACOL 2011 Vol.33(SUPPL 1),66 481643 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : Crude ethanolic extracts

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark :

Note : Data incomplete The aim of study was investigated four crude extracts with promising anticancer activity against chalangiocarcinoma i. e. extracts of Atractylodes lancea, Zingiber officinale, Piper chaba and Pra-sa-Prao-Yhai formulation.

หน้า 1

EN

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