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Part Used : เมล็ดActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 16-O-methylcafestolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5-500 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : 10 micromolar in phosphate bufferResult : PositiveRemark : In the initial solution, the warfarin - albumin complex is formed, and this is confirmed by the fact that after the addition of albumin, the warfarin emission is enhanced by about 70%. The fluorescence emission of warfarin is further increased upon the addition of the diterpenes in the low concentration range. This happens with both 16-O-methylcafestol and cafestol, despite the fact that their different effect on albumin tryptophan emission suggests a different mode of binding. This behavior as displace warfarin by competition in the binding site, rather than enhancing the affinity.
Part Used : เมล็ดActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : cafestolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5-500 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : 10 micromolar in phosphate bufferResult : PositiveRemark : In the initial solution, the warfarin - albumin complex is formed, and this is confirmed by the fact that after the addition of albumin, the warfarin emission is enhanced by about 70%. The fluorescence emission of warfarin is further increased upon the addition of the diterpenes in the low concentration range. This happens with both 16-O-methylcafestol and cafestol, despite the fact that their different effect on albumin tryptophan emission suggests a different mode of binding. This behavior as displace warfarin by competition in the binding site, rather than enhancing the affinity.
