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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : caffeic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - It was found that both caffeic acid and quercetin, major polyphenolic constituents of caffeine containing beverages, significantly inhibited CYP2A6 activity in vitro by 37.9% (P<0.05) and 48.2% (P<0.05), respectively.Note : - It is suggested that polyphenol interaction with CYP2A6 prolongs the pharmacological effects of nicotine by decreasing its rate of elimination.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : quercetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - It was found that both caffeic acid and quercetin, major polyphenolic constituents of caffeine containing beverages, significantly inhibited CYP2A6 activity in vitro by 37.9% (P<0.05) and 48.2% (P<0.05), respectively.Note : - It is suggested that polyphenol interaction with CYP2A6 prolongs the pharmacological effects of nicotine by decreasing its rate of elimination.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : VancomycinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : AmikacinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : CiprofloxacinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Erythromycin*/ErythrocinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : AmpicillinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Chlorogenic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : 24-48 hoursType of interaction : PharmacodynamicsInteraction with drug : Thiazolidinedione*/2,4-thiazolidinedioneDose/Conc.(drug) : 0-100 micromolarResult : PositiveRemark : - Thiazolidinedione (20 micromolar) in combination with ferulic acid (25 micromolar), eugenol (50 micromolar), chlorogenic acid (25 micromolar), caffeic acid (25 micromolar), and p-coumaric acid (25 micromolar) increased 2DG uptake by 7-, 6.8-, 6.7-, 6.5-, and 6.34-fold, respectively, with respect to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Chlorogenic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : 24-48 hoursType of interaction : PharmacodynamicsInteraction with drug : MetforminDose/Conc.(drug) : 0-100 micromolarResult : PositiveRemark : - Metformin (20 micromolar) with ferulic acid (25 micromolar), eugenol (25 micromolar), chlorogenic acid (25 micromolar), p-coumaric acid (25 micromolar), caffeic acid (25 micromolar), and cinnamic acid (25 micromolar) increased 2DG uptake by 6.5-, 6.4-, 6.2-, 6.1-, 6.3-, and 5.9-fold, respectively, when compared to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Levothyroxine*/T4/L-ThyroxineDose/Conc.(drug) :Result : PositiveRemark : In particular, certain foods and drinks affect the absorption of levothyroxine: in particular, dietary fibers, grapes, soybeans, papaya and coffee reduce the absorption of the drug.Note : Data from review
