ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : CYP2B2 INHIBITION

Solvent/Active Compound : kahweol and cafestol B

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Non-specified

Dose/Conc.(herb) : 0.2% K/C (1:1) in the diet

Duration : 10 days

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : K/C decreased the metabolism of four resorufin derivatives representing CYP1A1, CYP1A2, CYP2B1, and CYP2B2 activities by 50%. For CYP1A2, inhibition was confirmed at the mRNA level, accompanied by decreased CYP3A9. In contrast to K/C, coffee increased the metabolism of the resorufin derivatives up to 7-fold which was only marginally influenced by filtering. CYP2E1 activity and mRNA remained unchanged by K/C and coffee. K/C but not coffee decreased SULT by 25%. In summary, K/C inhibited CYP450s by tendency but not universally. Inhibition of CYP450 and SULT may contribute to chemoprevention with K/C but involvement in the protection of coffee drinkers is unlikely.

Note : K= kahweol C= cafestol Data incomplete

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