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Part Used : ไม่ระบุ

Activity : CYP1A2 INDUCTION

Solvent/Active Compound : -

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 5% wt/wt in diet

Duration : 2 weeks

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Coffee increased the expression of CYP1A2 by 16-fold in the 5% coffee treated group, and approximately half of this induction effect was attributed to caffeine. Coffee also increased the expression of glutathione S-transferase alpha was observed, UDP-glucuronosyltransferase (UGTs) activities of p-nitrophenol increased 2-fold.

Note : Data incomplete

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