ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : DRUG INTERACTION

Solvent/Active Compound : decaffeinated coffee

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Atorvastatin

Dose/Conc.(drug) : 10 mg/kg/day

Result : Positive

Remark : Type of experiment: Rat received 3-day atorvastatin (ATV) (10 mg/kg/day) or water by oral gavage once daily. Drinking water was replaced by water + sugar (7.5 g/100 mL), caffeinated coffee (CC) with sugar, or decaffeinated coffee (DC) with sugar. Results: CC, but not DC, abrogated the infarct size-limiting effects of ATV by blocking the adenosine receptors and preventing the phosphorylation of Akt. CC did not affect infarct size in rats not receiving ATV.

Note : Data incomplete

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