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MYRTACEAE Syzygium aromaticum (L.) Merr. & L.M.Perry

Synonym

MYRTACEAE Eugenia aromatica Kuntze
MYRTACEAE Eugenia caryophyllata Thunb.
MYRTACEAE Eugenia caryophyllus (Spreng.) Bullock & S.G.Harrison

Thai / English name

กานพลู*

[1-3] of 3 article(s) found

หน้า 1

[1] IN VITRO INHIBITION OF HUMAN CYTOCHROME P450-MEDIATED METABOLISM OF MARKER SUBSTRATES BY NATURAL PRODUCTS.
FOSTER BC,VANDENHOEK S,HANA J,ET AL.
PHYTOMEDICINE 2003 Vol.10(),334-42 $11159 [Full]

Part Used : ดอก
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : Aqueous extracts

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 94.0+/-2.21

[2] CYP3A4 AND CYP2D6 INHIBITORY ACTIVITIES OF INDONESIAN MEDICINAL PLANTS.
USIA T,IWATA H,HIRATSUKA A,ET AL.
PHYTOMEDICINE 2006 Vol.13(),67-73 $14378 [Full]

Part Used : ดอก
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : methanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1.65 mg/ml of water extract powder

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Erythromycin*/Erythrocin
Dose/Conc.(drug) : -

Result : Positive

Remark : Among the MeOH-soluble fractions, Piper nigrum leaf showed the highest inhibitory activity against CYP3A4 (91.7%) and Punica granatum against CYP2D6 (98.1%). The water extract MeOH-soluble fraction showed inhibitory activity more than 70% were fractionated with EtOAc. The most potent inhibitory activity against CYP3A4 (IC50 avlue of 25 mg/ml) was found for the extract of Pi. nigrum leaf, while that of Catharanthus roseus showed the most potent inhibitory effect against CYP2D6 (IC50 value of 11 mg/ml).

Note : Ketoconazole and quinidine (1 micromolar) were used as the positive control for CYP3A4 and CYP2D6, respectively.

Part Used : ดอก
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : ethylacetate

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1.65 mg/ml of water extract powder

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Erythromycin*/Erythrocin
Dose/Conc.(drug) : -

Result : Positive

Remark : Among the MeOH-soluble fractions, Piper nigrum leaf showed the highest inhibitory activity against CYP3A4 (91.7%) and Punica granatum against CYP2D6 (98.1%). The water extract MeOH-soluble fraction showed inhibitory activity more than 70% were fractionated with EtOAc. The most potent inhibitory activity against CYP3A4 (IC50 avlue of 25 mg/ml) was found for the extract of Pi. nigrum leaf, while that of Catharanthus roseus showed the most potent inhibitory effect against CYP2D6 (IC50 value of 11 mg/ml).

Note : Ketoconazole and quinidine (1 micromolar) were used as the positive control for CYP3A4 and CYP2D6, respectively.

[3] EFFECTS OF MACE AND NUTMEG ON HUMAN CYTOCHROME P450 3A4 AND 2C9 ACTIVITY.
KIMURA Y,ITO H,HATANO T
BIOL PHARM BULL 2010 Vol.33(12),1977-82 $33078 [Full]

Part Used : ไม่ระบุ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark :

หน้า 1

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