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| Thai / English name |
Part Used : ดอกActivity : CYP3A4 INHIBITIONSolvent/Active Compound : methanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.65 mg/ml of water extract powderDuration : -Type of interaction : PharmacokineticsInteraction with drug : Erythromycin*/ErythrocinDose/Conc.(drug) : -Result : PositiveRemark : Among the MeOH-soluble fractions, Piper nigrum leaf showed the highest inhibitory activity against CYP3A4 (91.7%) and Punica granatum against CYP2D6 (98.1%). The water extract MeOH-soluble fraction showed inhibitory activity more than 70% were fractionated with EtOAc. The most potent inhibitory activity against CYP3A4 (IC50 avlue of 25 mg/ml) was found for the extract of Pi. nigrum leaf, while that of Catharanthus roseus showed the most potent inhibitory effect against CYP2D6 (IC50 value of 11 mg/ml).Note : Ketoconazole and quinidine (1 micromolar) were used as the positive control for CYP3A4 and CYP2D6, respectively.
Part Used : ดอกActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ethylacetateType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1.65 mg/ml of water extract powderDuration : -Type of interaction : PharmacokineticsInteraction with drug : Erythromycin*/ErythrocinDose/Conc.(drug) : -Result : PositiveRemark : Among the MeOH-soluble fractions, Piper nigrum leaf showed the highest inhibitory activity against CYP3A4 (91.7%) and Punica granatum against CYP2D6 (98.1%). The water extract MeOH-soluble fraction showed inhibitory activity more than 70% were fractionated with EtOAc. The most potent inhibitory activity against CYP3A4 (IC50 avlue of 25 mg/ml) was found for the extract of Pi. nigrum leaf, while that of Catharanthus roseus showed the most potent inhibitory effect against CYP2D6 (IC50 value of 11 mg/ml).Note : Ketoconazole and quinidine (1 micromolar) were used as the positive control for CYP3A4 and CYP2D6, respectively.
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : Clove oil (eugenol)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Erythromycin*/ErythrocinDose/Conc.(drug) : -Result : PositiveRemark : Results: The concentration of antibiotics in the combination is 5-1000 fold lower than when used alone indicating that the combination is synergistic in nature.Note : The minimum inhibitory concentration (MIC) of antibiotics and eugenol is determined with 10^5 CFU/ml of colonies by adjusting the optical density at 600 nm and growing them on appropriate agar plates.
Part Used : ดอกActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Clove oil (eugenol)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Erythromycin*/ErythrocinDose/Conc.(drug) : -Result : PositiveRemark : Results: The concentration of antibiotics in the combination is 5-1000 fold lower than when used alone indicating that the combination is synergistic in nature.Note : The minimum inhibitory concentration (MIC) of antibiotics and eugenol is determined with 10^5 CFU/ml of colonies by adjusting the optical density at 600 nm and growing them on appropriate agar plates.
