ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : CYP1A1 INDUCTION

Solvent/Active Compound : delta-9-tetrahydrocannabinol (delta9-THC)

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

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Type of interaction : Pharmacodynamics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Delta-9 tetrahydrocannibinol (delta9-THC) and cannabidiol (CBD) increased the expression of CYP1A1 mRNA in a concentration-dependent manner; CYP1A1 mRNA level at 50 micromolar delta9-THC and CBD were 1.7- and 4.8- fold higher, respectively than control level. CBN had a less marked effect on CYP1A1 expression.

Note : Investigated the inducibility of cytochrome P450 1A1 (CYP1A1) by delta-9-tetrahydrocannabinol (delta9-THC) cannabidiol (CBD), and cannabinol (CBN), three major phytocannabinoids, using human hepatoma HepG2 cells. The expression of CYP1A1 and the aryl hydrocarbon receptor (AhR) was measured by a quantitative real-time polymerase chain reaction and/or Western blotting.

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