| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 15N(Treatment) : -Sex : Both sexAge : 78+-/6 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Antihypertensive drugsDose/Conc.(drug) : -Result : PositiveRemark : Result: Garlic + Antihypertensive drugs = Additive hypotensive effect (No. Potential or Possible Interactions = 12 of 45)Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 15N(Treatment) : -Sex : Both sexAge : 78+-/6 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Antihypertensive drugsDose/Conc.(drug) : -Result : PositiveRemark : Result: Garlic + Antidiabetic drugs = Additive hypoglycemic effect (No. Potential or Possible Interactions = 2 of 45)Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 15N(Treatment) : -Sex : Both sexAge : 78+-/6 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Aspirin*/Acetylsalicylic acid/ASA/EcosprinDose/Conc.(drug) : -Result : PositiveRemark : Result: Garlic + Aspirin or another NSAID = Increased risk of bleeding (No. Potential or Possible Interactions = 10 of 45)Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 15N(Treatment) : -Sex : Both sexAge : 78+-/6 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClopidogrelDose/Conc.(drug) : -Result : PositiveRemark : Result: Garlic + Clopidogrel = Increased risk of bleeding (No. Potential or Possible Interactions = 1 of 45)Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 15N(Treatment) : -Sex : Both sexAge : 78+-/6 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Result: Garlic + warfarin = Increased risk of bleeding (No. Potential or Possible Interactions = 1 of 45)Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 200 (M/F = 196/4)N(Treatment) : 1Sex : Both sexAge : Median age of patients was 68 years (range, 36-82 years)Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Daonil*/Glyburide/Glibenclamide/Diadeta/Glybenclamide/GlybenzcyclamideDose/Conc.(drug) : -Result : PositiveRemark : Potential interaction : increased hypoglycemic.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 11,424N(Treatment) : -Sex : Both sexAge : >/=18 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : 2000-2001Type of interaction : PharmacokineticsInteraction with drug : SulfonylureaDose/Conc.(drug) : -Result : PositiveRemark : Ginkgo was associated with the potential for modulate hyperglycemia due to combined use with sulfonylurea.Note : Subjects: Of the adult National population Health Survey respondents (n=11,424), 9.3% reported the use of at least 1 natural health product in the past 2 days in 2000-2001.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times dailyDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 8 mgResult : NegativeRemark :Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times dailyDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : CaffeineDose/Conc.(drug) : 100 mgResult : PositiveRemark :Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times dailyDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : 500 mgResult : PositiveRemark : Garlic oil produced a significant decerease (P=0.005) of 22% in 6-hydroxychlorzoxazone/chlorzoxazone serum ratios.Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
