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AMARYLLIDACEAE Allium sativum L.

Synonym

none ...

Thai / English name

กระเทียม*

[1-4] of 4 article(s) found

หน้า 1

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound :

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Mild inhibition of Pgp in vitro.

Note : Data incomplete, data from review article.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.

Note : Data from review, data incomplete.

[3] ENHANCING ACTIVITY OF ANTICANCER DRUGS IN MULTIDRUG RESISTANT TUMORS BY MODULATING P-GLYCOPROTEIN THROUGH DIETARY NUTRACEUTICALS.
MUHAMMAD KHAN,AMARA MARYAM,TAHIR MEHMOOD,ET AL.
ASIAN PAC J CANCER PREV 2015 Vol.16(16),6831-9 $59875 [Full]

Part Used : หัว
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : DAS (Diallyl sulfide) and DATS (Diallyl trisulfide)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Vinblastine*/VLB
Dose/Conc.(drug) : -

Result : Positive

Remark : DAS also inhibited the vinblastine induced expression of p-gp in normal mouse liver.

Note : Data from review

[4] EFFECTS OF DIETARY CHEMOPREVENTIVE PHYTOCHEMICALS ON P-GLYCOPROTEIN FUNCTION.
NABEKURA T,KAMIYAMA S,KITAGAWA S
BIOCHEM BIOPHYS RES COMMUN 2005 Vol.327(3),866-70 407084 [Abstract]

Part Used : -
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : diallyl sulfide and diallyl trisulfide

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Daunorubicin*/Daunomycin/Rubidomycin
Dose/Conc.(drug) : -

Result : Negative

Remark : Sulforaphane, indole-3-carbinol, and diallyl sulfide and diallyl trisulfide had no effect on P-glycoprotein.

หน้า 1

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