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Part Used : หัวActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 125 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : หัวActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : หัวActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : ไม่ระบุActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : DiltiazemDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : DiltiazemDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : Verapamil*/IproveratrilDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : SUPEROXIDE DISMUTASE STIMULATIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : Verapamil*/IproveratrilDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
