Synonym |
Thai / English name |
Part Used : หัวActivity : CYP3A7 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Garlic constituents have been shown to modulate the activity of various CYP isozymes in vitro. These constituents exhibit and inhibitory effect on CYP2C9* 1, CYP2C19, CYP3A4, CYP3A5, and CYP3A7 metabolism, whereas no effect on CYP2D6 was observed.Note : Data incomplete, data from review article
Part Used : หัวActivity : CYP3A7 INHIBITIONSolvent/Active Compound : fresh and aged garlic extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Garlic extracts, both fresh and aged, were responsible for the inhibition of CYP3A4 in human liver microsomes, and complementary DNA (cDNA) - expressed CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7 activities.Note : Data incomplete, data from review article