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Part Used : น้ำมันActivity : CYP2E1 INHIBITIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times dailyDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : 500 mgResult : PositiveRemark : Garlic oil produced a significant decerease (P=0.005) of 22% in 6-hydroxychlorzoxazone/chlorzoxazone serum ratios.Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound :Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Phenothiazines*/Phenothiazine/PTZ/10H-Phenothiazine/ThiodiphenylamineDose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound :Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
Part Used : หัวActivity : CYP2E1 INHIBITIONSolvent/Active Compound : diallyl sulfide, diallyl disulfide, allyl methyl sulfide, and allyl mercaptanType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Treatment of rats with diallyl sulfide, diallyl disulfide, allyl methyl sulfide, and allyl mercaptan showed a suppression of CYP2E1 activity as a result of competitive inhibition. In addition, diallyl sulfone is known to be a suicide inhibitor of CYP2E1 via complex formation that leads to its autocatalytic destruction.Note : Data incomplete, data from review article
Part Used : หัวActivity : CYP2E1 INHIBITIONSolvent/Active Compound : garlic oilType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 12N(Treatment) : 12Sex : -Age : 60-76 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : -Result : PositiveRemark : In a study using chlozoxazone as a probe, garlic oil administration for 28 days to healthy volunteers reduced CYP2E1 activity by 39%.Note : Data incomplete, data from review article
Part Used : หัวActivity : CYP2E1 INHIBITIONSolvent/Active Compound : garlic oilType of experiment : in vivoType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : Single doseType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Single dose of garlic oil in rats was responsible for a significant inhibition of hepatic CYP-catalyzed reactions including aminopyrine N - demethylase (CYP2C) and aniline hydroxylase (CYP2E1) activity, though 5 days administration of garlic led to a significant increase in these hepatic CYP activities.Note : Data incomplete, data from review article
Part Used : หัวActivity : CYP2E1 INHIBITIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) :Result : PositiveRemark : An animal study in mice indicated that garlic - derived diallyl sulfone (DASO2) decreased the plsma concentrations of oxidative acetaminophen metabolites but not of nonoxidative acetaminophen metabolites, due to the inhibition of CYP2E1, which is the major enzyme responsible for the bioactivation of acetaminophen.Note : Data incomplete, data from review article
