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Part Used : หัวActivity : CYP2C19 INHIBITIONSolvent/Active Compound : allicinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 98 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : PositiveRemark : Results: lC50 values (micromolar) of test compounds for CYP1A2 inhibition = 44.22 micromolar lC50 values (micromolar) of test compounds for CYP2C9 inhibition = 5.14 micromolar lC50 values (micromolar) of test compounds for CYP2C19 inhibition = 3.52 micromolar lC50 values (micromolar) of test compounds for CYP2D6 inhibition = 47.10 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BzRes) inhibition = 60.10 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BFC) inhibition = 43.73 micromolarNote : Evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments. Increasing concentrations of the compounds were incubated with a panel of recombinant human CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) and their effects on the conversion of specific surrogate substrates measured fluorometrically in a 96-well plate format.
Part Used : หัวActivity : CYP2C19 INHIBITIONSolvent/Active Compound : dihydromethysticinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 180 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : PositiveRemark : Results: lC50 values (micromolar) of test compounds for CYP1A2 inhibition = 14.8 micromolar lC50 values (micromolar) of test compounds for CYP2C9 inhibition = 13.35 micromolar lC50 values (micromolar) of test compounds for CYP2C19 inhibition = 0.43 micromolar C50 values (micromolar) of test compounds for CYP2D6 inhibition = 37.03 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BzRes) inhibition = 11.4 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BFC) inhibition = 2.49 micromolarNote : Evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments. Increasing concentrations of the compounds were incubated with a panel of recombinant human CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) and their effects on the conversion of specific surrogate substrates measured fluorometrically in a 96-well plate format.
Part Used : หัวActivity : CYP2C19 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 18N(Treatment) : 18Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : allicin capsule 180 mg once dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : OmeprazoleDose/Conc.(drug) : -Result : PositiveRemark : The results of this study demonstrate that allicin reduces the metabolism of omeprazole by inhibiting CYP2C19 activity in healthy Chinese male subjects with the genotype CYP2C19*1/CYP2C19*1 or CYP2C19*1/CYP2C19*2 or*3 but not CYP2C19*2/CYP2C19*2. Allicin did not significantly affect the activity of CYP3A4 in all subjects after 14 days of exposure.Note : - Eighteen subjects (six CYP2C19*1/CYP2C19*1, four CYP2C19*1/CYP2C19*2, two CYP2C19*1/CYP2C19*3, and six CYP2C19*2/CYP2C19*2) - On the 15th day, all subjects were given a single oral dose of omeprazole (20 mg capsule) with 250 ml of warm water after an overnight fast.
Part Used : หัวActivity : CYP2C19 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Garlic constituents have been shown to modulate the activity of various CYP isozymes in vitro. These constituents exhibit and inhibitory effect on CYP2C9* 1, CYP2C19, CYP3A4, CYP3A5, and CYP3A7 metabolism, whereas no effect on CYP2D6 was observed.Note : Data incomplete, data from review article
Part Used : หัวActivity : CYP2C19 INHIBITIONSolvent/Active Compound : fresh and aged garlic extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Garlic extracts, both fresh and aged, were responsible for the inhibition of CYP3A4 in human liver microsomes, and complementary DNA (cDNA) - expressed CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7 activities.Note : Data incomplete, data from review article
