ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : หัว

Activity : CYP2C INHIBITION

Solvent/Active Compound : garlic oil

Type of experiment : in vivo

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : -

Duration : Single dose

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Single dose of garlic oil in rats was responsible for a significant inhibition of hepatic CYP-catalyzed reactions including aminopyrine N - demethylase (CYP2C) and aniline hydroxylase (CYP2E1) activity, though 5 days administration of garlic led to a significant increase in these hepatic CYP activities.

Note : Data incomplete, data from review article

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