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| Thai / English name |
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times dailyDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : 500 mgResult : PositiveRemark : Garlic oil produced a significant decerease (P=0.005) of 22% in 6-hydroxychlorzoxazone/chlorzoxazone serum ratios.Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : น้ำมันActivity : CYP2E1 INHIBITIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times dailyDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : 500 mgResult : PositiveRemark : Garlic oil produced a significant decerease (P=0.005) of 22% in 6-hydroxychlorzoxazone/chlorzoxazone serum ratios.Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : หัวActivity : CYP2E1 INHIBITIONSolvent/Active Compound : garlic oilType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 12N(Treatment) : 12Sex : -Age : 60-76 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : -Result : PositiveRemark : In a study using chlozoxazone as a probe, garlic oil administration for 28 days to healthy volunteers reduced CYP2E1 activity by 39%.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic oilType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 12N(Treatment) : 12Sex : -Age : 60-76 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : -Result : PositiveRemark : In a study using chlozoxazone as a probe, garlic oil administration for 28 days to healthy volunteers reduced CYP2E1 activity by 39%.Note : Data incomplete, data from review article
