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Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : diallyl disulfideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Cyclophosphamide*/CPM/CTX/CYTDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment = maternal liver and placentaNote : Diallyl disulfide (DADS) treatment significantly attenuated cyclophosphamide-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver placenta.
Part Used : -Activity : CYP3A1 INDUCTIONSolvent/Active Compound : diallyl disulfideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Cyclophosphamide*/CPM/CTX/CYTDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment = maternal liver and placentaNote : Diallyl disulfide (DADS) treatment significantly attenuated cyclophosphamide-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver placenta.