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Thai / English name |
Part Used : หัวActivity : CYP2C19 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 18N(Treatment) : 18Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : allicin capsule 180 mg once dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : OmeprazoleDose/Conc.(drug) : -Result : PositiveRemark : The results of this study demonstrate that allicin reduces the metabolism of omeprazole by inhibiting CYP2C19 activity in healthy Chinese male subjects with the genotype CYP2C19*1/CYP2C19*1 or CYP2C19*1/CYP2C19*2 or*3 but not CYP2C19*2/CYP2C19*2. Allicin did not significantly affect the activity of CYP3A4 in all subjects after 14 days of exposure.Note : - Eighteen subjects (six CYP2C19*1/CYP2C19*1, four CYP2C19*1/CYP2C19*2, two CYP2C19*1/CYP2C19*3, and six CYP2C19*2/CYP2C19*2) - On the 15th day, all subjects were given a single oral dose of omeprazole (20 mg capsule) with 250 ml of warm water after an overnight fast.
Part Used : หัวActivity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 18N(Treatment) : 18Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : allicin capsule 180 mg once dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : OmeprazoleDose/Conc.(drug) : -Result : NegativeRemark : The results of this study demonstrate that allicin reduces the metabolism of omeprazole by inhibiting CYP2C19 activity in healthy Chinese male subjects with the genotype CYP2C19*1/CYP2C19*1 or CYP2C19*1/CYP2C19*2 or*3 but not CYP2C19*2/CYP2C19*2. Allicin did not significantly affect the activity of CYP3A4 in all subjects after 14 days of exposure.Note : - Eighteen subjects (six CYP2C19*1/CYP2C19*1, four CYP2C19*1/CYP2C19*2, two CYP2C19*1/CYP2C19*3, and six CYP2C19*2/CYP2C19*2) - On the 15th day, all subjects were given a single oral dose of omeprazole (20 mg capsule) with 250 ml of warm water after an overnight fast.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 18N(Treatment) : 18Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : allicin capsule 180 mg once dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : OmeprazoleDose/Conc.(drug) : -Result : PositiveRemark : The results of this study demonstrate that allicin reduces the metabolism of omeprazole by inhibiting CYP2C19 activity in healthy Chinese male subjects with the genotype CYP2C19*1/CYP2C19*1 or CYP2C19*1/CYP2C19*2 or*3 but not CYP2C19*2/CYP2C19*2. Allicin did not significantly affect the activity of CYP3A4 in all subjects after 14 days of exposure.Note : - Eighteen subjects (six CYP2C19*1/CYP2C19*1, four CYP2C19*1/CYP2C19*2, two CYP2C19*1/CYP2C19*3, and six CYP2C19*2/CYP2C19*2) - On the 15th day, all subjects were given a single oral dose of omeprazole (20 mg capsule) with 250 ml of warm water after an overnight fast.