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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : p-coumaric acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : 24-48 hoursType of interaction : PharmacodynamicsInteraction with drug : MetforminDose/Conc.(drug) : 0-100 micromolarResult : PositiveRemark : - Metformin (20 micromolar) with ferulic acid (25 micromolar), eugenol (25 micromolar), chlorogenic acid (25 micromolar), p-coumaric acid (25 micromolar), caffeic acid (25 micromolar), and cinnamic acid (25 micromolar) increased 2DG uptake by 6.5-, 6.4-, 6.2-, 6.1-, 6.3-, and 5.9-fold, respectively, when compared to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Garlic extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 8 daysType of interaction : PharmacokineticsInteraction with drug : MetforminDose/Conc.(drug) : 320 mg/kgResult : PositiveRemark : Garlic is altering the pharmacokinetics of Metformin in rats by significantly increasing its Cmax and AUC0-12h. With repeated dose administration, a prominent effect is seen by a significant increase in Cmax, AUC0-12h and slight increase in t1/2.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 8 daysType of interaction : PharmacokineticsInteraction with drug : MetforminDose/Conc.(drug) : 320 mg/kgResult : PositiveRemark : Garlic is altering the pharmacokinetics of Metformin in rats by significantly increasing its Cmax and AUC0-12h. With repeated dose administration, a prominent effect is seen by a significant increase in Cmax, AUC0-12h and slight increase in t1/2.
