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Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic extractType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 14 (M/F=9/5)N(Treatment) : 14Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : garlic extract 600 mg tablet, 3 x 600 mg twice dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : NegativeRemark : The administration of a garlic extract (with an allicin potential of 600 micrograms; alliin, 1.5 mg; and S - allyl - L - cysteine, 0.03 mg in each 600 mg tablet, 3 x 600 mg twice daily) insignificantly increased the ratio of dextromethorphan to its metabolite from 0.044 at baseline to 0.052 (p> 0.05). No significant differences were seen in pharmacokinetic parameters (Cmax, AUC, t1/2) for alprazolam at baseline, and after garlic extract treatment.Note : Data incomplete, data from review article
Part Used : หัวActivity : PHARMACOKINETIC STUDY OFSolvent/Active Compound : garlic extractType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 14 (M/F=9/5)N(Treatment) : 14Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : garlic extract 600 mg tablet, 3 x 600 mg twice dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : NegativeRemark : The administration of a garlic extract (with an allicin potential of 600 micrograms; alliin, 1.5 mg; and S - allyl - L - cysteine, 0.03 mg in each 600 mg tablet, 3 x 600 mg twice daily) insignificantly increased the ratio of dextromethorphan to its metabolite from 0.044 at baseline to 0.052 (p> 0.05). No significant differences were seen in pharmacokinetic parameters (Cmax, AUC, t1/2) for alprazolam at baseline, and after garlic extract treatment.Note : Data incomplete, data from review article