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Part Used : กลีบเลี้ยงActivity : DRUG INTERACTIONSolvent/Active Compound : water / anthocyaninType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 300 ml (equivalent to 8.18 mg anthocyanins)Duration : 3 daysType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 25 mgResult : PositiveRemark : - The diclofenac excreted with co-administration of H. sabdariffa was much lower (0.56+/-0.17 microgram/mL) than with the control (0.90+/-0.50 microgram/mL) with a significant difference observed (p<0.05; 95% confidence interval means - 0.319; 0.037 to 0.602; F=7.069).Note : - There was a reduction in the amount of diclofenac excreted and the wide variability observed in the control with the water beverage of Hibiscus sabdariffa (p<0.05). There is an increasing need to counsel patients against the use of plant beverages with drugs.
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 40 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : -Result : PositiveRemark : Route* Intragastric tube - Effect of co-administration of HSE and HCT on diuresis in rats. - Co-administration of the extract (40 mg/kg) with HCT (10 mg/kg) caused a significant increase in the volume of urine excreted, as well as a significant decrease in the pH of urine and the concentrations of sodium bicarbonate and chloride ions.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 20 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : methanolicType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HSE 40 mg/kg B.W.Duration : -Type of interaction : PharmacokineticsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : กลีบเลี้ยงActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 6N(Treatment) : 6Sex : MaleAge : 28.50+/-1.76 yearsRoute : Oral administrationDose/Conc.(herb) : sweetened aqueous extract prepared from 30 g dried hibiscus calycesDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 10 mg/kgResult : NegativeRemark : - In the first phase on oral dose of acetaminophen (1 g) was administered to the volunteer and in the second phases, zobo drink (extract of H. Sabdariffa) was ingested by the volunteers 1.30 h prior the administration of acetaminophen (1 g). - No significant kinetic changes were observed when the extract was administered concomitanty with acetaminophen, except for a slight elevation of total body clearance (Clt) 11.69%.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : karkadiType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : Coadministration with drugType of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 600 mgResult : PositiveRemark : The mean AUC values after administration with water (control) and karkadi were 7.52 +/- 0.87 and 2.16 +/- 0.30, mg.h/L, respectively. The corresponding mean Cmax values were 553 +/- 17.8 and 184 +/- 21.3 mg/L and the corresponding Tmax values were 3.0 +/- 1.0 and 3.2 +/- 1.2 h for control and aradaib, respoectively. The results indicate a statistically significant reduction in the AUC and Cmax of chloroquine as a result of a coadministration with the aradaib beverages.Note : Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 6N(Treatment) : -Sex : MaleAge : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 600 mgResult : -Remark : The results indicate a statistically significant reduction in the area under the plasma concentrations versus time curve (AUC) and the peak plasma concentration (Cmax) of chloroquine as a result of a co-administration with each of the three beverages (T. indica, H. sabdariffa and C. limetta).Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
