Synonym |
Thai / English name |
Part Used : กลีบเลี้ยงActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 6N(Treatment) : 6Sex : MaleAge : 28.50+/-1.76 yearsRoute : Oral administrationDose/Conc.(herb) : sweetened aqueous extract prepared from 30 g dried hibiscus calycesDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 10 mg/kgResult : NegativeRemark : - In the first phase on oral dose of acetaminophen (1 g) was administered to the volunteer and in the second phases, zobo drink (extract of H. Sabdariffa) was ingested by the volunteers 1.30 h prior the administration of acetaminophen (1 g). - No significant kinetic changes were observed when the extract was administered concomitanty with acetaminophen, except for a slight elevation of total body clearance (Clt) 11.69%.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : กลีบเลี้ยงActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 6N(Treatment) : 6Sex : MaleAge : 28.50+/-1.76 yearsRoute : Oral administrationDose/Conc.(herb) : sweetened aqueous extract prepared from 30 g dried hibiscus calycesDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 10 mg/kgResult : NegativeRemark : - In the first phase on oral dose of acetaminophen (1 g) was administered to the volunteer and in the second phases, zobo drink (extract of H. Sabdariffa) was ingested by the volunteers 1.30 h prior the administration of acetaminophen (1 g). - No significant kinetic changes were observed when the extract was administered concomitanty with acetaminophen, except for a slight elevation of total body clearance (Clt) 11.69%.Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide