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Part Used : กลีบเลี้ยงActivity : DRUG INTERACTIONSolvent/Active Compound : water / anthocyaninType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 300 ml (equivalent to 8.18 mg anthocyanins)Duration : 3 daysType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 25 mgResult : PositiveRemark : - The diclofenac excreted with co-administration of H. sabdariffa was much lower (0.56+/-0.17 microgram/mL) than with the control (0.90+/-0.50 microgram/mL) with a significant difference observed (p<0.05; 95% confidence interval means - 0.319; 0.037 to 0.602; F=7.069).Note : - There was a reduction in the amount of diclofenac excreted and the wide variability observed in the control with the water beverage of Hibiscus sabdariffa (p<0.05). There is an increasing need to counsel patients against the use of plant beverages with drugs.
Part Used : กลีบเลี้ยงActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : water / anthocyaninType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 300 ml (equivalent to 8.18 mg anthocyanins)Duration : 3 daysType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 25 mgResult : PositiveRemark : - The diclofenac excreted with co-administration of H. sabdariffa was much lower (0.56+/-0.17 microgram/mL) than with the control (0.90+/-0.50 microgram/mL) with a significant difference observed (p<0.05; 95% confidence interval means - 0.319; 0.037 to 0.602; F=7.069).Note : - There was a reduction in the amount of diclofenac excreted and the wide variability observed in the control with the water beverage of Hibiscus sabdariffa (p<0.05). There is an increasing need to counsel patients against the use of plant beverages with drugs.
