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MALVACEAE Hibiscus sabdariffa L.

Synonym

none ...

Thai / English name

กระเจี๊ยบแดง*

[1-2] of 2 article(s) found

หน้า 1

[1] SIGNIFICANT REDUCTION IN CHLOROQUINE BIOAVAILABILITY FOLLOWING COADMINISTRATION WITH THE SUDANESE BEVERAGES ARADAIB, KARKADI AND LEMON.
MAHMOUD BM,ALI HM,HOMEIDA MM,ET AL.
J ANTIMICROB CHEMOTHER 1994 Vol.33(5),1005-9 371285 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : karkadi

Type of experiment : human
Type of animal : -

Type of study : non specified

N(Total) : -
N(Treatment) : -

Sex : Male
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : Coadministration with drug
Type of interaction : Pharmacokinetics

Interaction with drug : Chloroquine*/Chloroquine sulphate
Dose/Conc.(drug) : 600 mg

Result : Positive

Remark : The mean AUC values after administration with water (control) and karkadi were 7.52 +/- 0.87 and 2.16 +/- 0.30, mg.h/L, respectively. The corresponding mean Cmax values were 553 +/- 17.8 and 184 +/- 21.3 mg/L and the corresponding Tmax values were 3.0 +/- 1.0 and 3.2 +/- 1.2 h for control and aradaib, respoectively. The results indicate a statistically significant reduction in the AUC and Cmax of chloroquine as a result of a coadministration with the aradaib beverages.

Note : Data incomplete.

[2] SIGNIFICANT REDUCTION IN CHLOROQUINE BIOAVAILABLITY FOLLOWING COADMINISTRATION WITH THE SUDANESE BEVERAGES ARADAIB, KARKADI AND LEMON.
B. M. MAHMOUD,H. M. ALI,M. M. A. HOMEIDA,ET AL.
J ANTIMICROB CHEMOTHER 1994 Vol.33(5),1005-9 491215 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Open trial

N(Total) : 6
N(Treatment) : -

Sex : Male
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Chloroquine*/Chloroquine sulphate
Dose/Conc.(drug) : 600 mg

Result : -

Remark : The results indicate a statistically significant reduction in the area under the plasma concentrations versus time curve (AUC) and the peak plasma concentration (Cmax) of chloroquine as a result of a co-administration with each of the three beverages (T. indica, H. sabdariffa and C. limetta).

Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide

Part Used : ไม่ระบุ
Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Open trial

N(Total) : 6
N(Treatment) : -

Sex : Male
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Chloroquine*/Chloroquine sulphate
Dose/Conc.(drug) : 600 mg

Result : -

Remark : The results indicate a statistically significant reduction in the area under the plasma concentrations versus time curve (AUC) and the peak plasma concentration (Cmax) of chloroquine as a result of a co-administration with each of the three beverages (T. indica, H. sabdariffa and C. limetta).

Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide

หน้า 1

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