| Synonym |
| Thai / English name |
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : Furanocoumarins, Fruit juices of 'changshanhuyou' (Citrus changshanhuyou Y.B. Chang)Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : 250 mL of fruit juices of Changshanhuyou with 26-mmol (10-mg) plain tablet felodipine.Duration : Observed for 12 h after administration of drugType of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) : 26-mmol (10-mg) plain tablet felodipineResult : PositiveRemark : Results: The geometric mean and 90% confidence intervals of pharmacokinetic parameters for human oral felodipine with C. paradisi, C. grandis Osbeck vs. Guanxi, C. changshanhuyou Y.B. Chang and water were respectively as follows: peak plasma concentration (nmol.bul.L-1), 37 (32-44), 25 (21-29), 19 (16-22) and 18 (15-21); area under the plasma concentration-time curve (nmol.bul.h.bul.L-1), 118 (103-136), 84 (73-97), 64 (56-74) and 59 (51-68). Subjects showed higher heart rates with C. paradisi Macf than with C. changshanhuyou Y.B. Chang or water. *Subject total: Subjects were healthy volunteers.Note : Data incomplete.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : Furanocoumarins, Fruit juices of pummel grapefruit (Citrus paradisi Mscf)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : -Dose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : PositiveRemark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang had none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.Note : Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : LemonType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : Coadministration with drugType of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 600 mgResult : PositiveRemark : The mean AUC values after administration with water (control) and lemon were 7.52 +/- 0.87 and 2.41 +/- 0.29, mg.h/L, respectively. The corresponding mean Cmax values were 553 +/- 17.8 and 184 +/- 21.3 mg/L and the corresponding Tmax values were 3.0 +/- 1.0 and 3.2 +/- 1.2 h for control and aradaib, respoectively. The results indicate a statistically significant reduction in the AUC and Cmax of chloroquine as a result of a coadministration with the aradaib beverages.Note : Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 6N(Treatment) : -Sex : MaleAge : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 600 mgResult : -Remark : The results indicate a statistically significant reduction in the area under the plasma concentrations versus time curve (AUC) and the peak plasma concentration (Cmax) of chloroquine as a result of a co-administration with each of the three beverages (T. indica, H. sabdariffa and C. limetta).Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : grapefruit juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 9N(Treatment) : 9Sex : MaleAge : middle-agedRoute : Oral administrationDose/Conc.(herb) :Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : FelodipineDose/Conc.(drug) : Felodipine 5 mg plain tabletResult : PositiveRemark : Result: Compared to water, grapefruit juice caused an increase in Cmax from mean 6 to 16 nmol.l-1, and in the AUC from 23 to 65 nmol.h.l-1. The change in AUC corresponded to an increase in the systemic availability of felodipine from 15 to 45%, assuming no change in its clearance. The higher plasma concentrations of felodipine taken with grapefruit juice resulted in a greater change in blood pressure measured in the morning 3 h after dosing (-9%) than did water (0%).Note : Data incomplete
