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Part Used : เปลือกผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : geranylcoumarinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Geranylcoumarin was found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 42.93 micromolar.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : 3,5,6,7,8,3',4'-heptamethoxyflavone, 3,5,6,7,3',4'-hexamethoxyflavone (quercetagetin hexamethyl ether), 5,6,7,3',4'-pentamethoxyflavone (sinensetin) และ 5,6,7,8,3',4'-hexamethoxyflavone (nobiletin)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: สารที่แยกได้จากน้ำส้มเช้ง ได้แก่ 3,5,6,7,8,3',4'-heptamethoxyflavone, 3,5,6,7,3',4'-hexamethoxyflavone (quercetagetin hexamethyl ether), 5,6,7,3',4'-pentamethoxyflavone (sinensetin) และ 5,6,7,8,3',4'-hexamethoxyflavone (nobiletin) มีฤทธิ์ยังยั้งการทำงานของ Pgp โดยไม่มีผลต่อการทำงานของ CYP3A4Note : Data incomplete
Part Used : เปลือกผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Furanocoumarins (FCs) (bergamottin (BG) and 6,7-dihydroxybergamottin (DHBG)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: CYP3A inhibitory activities of crystd. grapefruit peel, grapefruit marmalade, lemon peel and bitter orange slice were close to that of 100% grapefruit juice.Note : The max, BG content was 5.6 microgram/g in lemon peel. The max. DHBG content was 7.2 microgram/g in crystd. grapefruit peel, about 1/30 that of raw peel. Grapefruit marmalade and crystd.grapefruit peel contained similar amts. of FCs to 100% grapefruit juice, but FCs were not detected in pomelo (buntan) marmalade or crystd. iyokan peel. Good correlation (r = 0.78) was obsd. between the FC contents of these peel products and those CYP3A inhibitory activities. Prepn. of homemade grapefruit marmalade and crystd. peel revealed that considerably lower DHBG content in these products and lower CYP3A inhibitory activity than anticipated were attributable to outflow of DHBG to broth during boiling of the raw peel. Data incomplete
Part Used : เปลือกผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Furanocoumarins (FCs) (bergamottin (BG) and 6,7-dihydroxybergamottin (DHBG)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: CYP3A inhibitory activities of crystd. grapefruit peel, grapefruit marmalade, lemon peel and bitter orange slice were close to that of 100% grapefruit juice.Note : The max, BG content was 5.6 microgram/g in lemon peel. The max. DHBG content was 7.2 microgram/g in crystd. grapefruit peel, about 1/30 that of raw peel. Grapefruit marmalade and crystd.grapefruit peel contained similar amts. of FCs to 100% grapefruit juice, but FCs were not detected in pomelo (buntan) marmalade or crystd. iyokan peel. Good correlation (r = 0.78) was obsd. between the FC contents of these peel products and those CYP3A inhibitory activities. Prepn. of homemade grapefruit marmalade and crystd. peel revealed that considerably lower DHBG content in these products and lower CYP3A inhibitory activity than anticipated were attributable to outflow of DHBG to broth during boiling of the raw peel. Data incomplete
