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Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Changshanhuyou (Citrus changshanhuyou Y.B. Chang)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : PositiveRemark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang hand none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.Note : Data incomplete.
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Changshanhuyou (Citrus changshanhuyou Y.B. Chang)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : PositiveRemark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang hand none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.Note : Data incomplete.
Part Used : น้ำจากผลActivity : CYP3A5 INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of pummel grapefruit (Citrus paradisi Macf)Type of experiment : in vitroType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : EquivocalRemark : Results: CYP3A5* polymorphism showed no significant effect on felodipine pharmacokinetics and related hemodynamic changes. This work supports the hypothesis that CYP3A inhibition by furanocoumarins caused pummelo fruit juice drug interaction; while the role of CYP3A5 in the population pharmacokinetics of felodipine and blood pressure response appear to be limited.Note : Data incomplete.
Part Used : น้ำจากผลActivity : CYP3A5 INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Changshanhuyou (Citrus changshanhuyou y.B. Chang)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : -Dose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : EquivocalRemark : Results: CYP3A5* polymorphism showed no significant effect on felodipine pharmacokinetics and related hemodynamic changes. This work supports the hypothesis that CYP3A inhibition by furanocoumarins caused pummelo fruit juice drug interaction; while the role of CYP3A5 in the population pharmacokinetics of felodipine and blood pressure response appear to be limited.Note : Data incomplete.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : grapefruit juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 9N(Treatment) : 9Sex : MaleAge : middle-agedRoute : Oral administrationDose/Conc.(herb) :Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : FelodipineDose/Conc.(drug) : Felodipine 5 mg plain tabletResult : PositiveRemark : Result: Compared to water, grapefruit juice caused an increase in Cmax from mean 6 to 16 nmol.l-1, and in the AUC from 23 to 65 nmol.h.l-1. The change in AUC corresponded to an increase in the systemic availability of felodipine from 15 to 45%, assuming no change in its clearance. The higher plasma concentrations of felodipine taken with grapefruit juice resulted in a greater change in blood pressure measured in the morning 3 h after dosing (-9%) than did water (0%).Note : Data incomplete
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : grapefruit juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 9N(Treatment) : 9Sex : MaleAge : middle-agedRoute : Oral administrationDose/Conc.(herb) :Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : FelodipineDose/Conc.(drug) : Felodipine 5 mg plain tabletResult : PositiveRemark : Result: Compared to water, grapefruit juice caused an increase in Cmax from mean 6 to 16 nmol.l-1, and in the AUC from 23 to 65 nmol.h.l-1. The change in AUC corresponded to an increase in the systemic availability of felodipine from 15 to 45%, assuming no change in its clearance. The higher plasma concentrations of felodipine taken with grapefruit juice resulted in a greater change in blood pressure measured in the morning 3 h after dosing (-9%) than did water (0%).Note : Data incomplete
