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Part Used : ต้นอ่อนActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Sulforaphane (SFN)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age :Route : Oral administrationDose/Conc.(herb) : 100 mg/kg/dayDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: Female mice were split into four groups: (a) received vehicle, (b) 10 mg/kg/day rifampicin, (c) 100 mg/kg/day SFN, and (d) 10 mg/kg/day rifampicin and 100 mg/kg/day SFN. Mice were administered SFN and/or rifampicin by gavage daily for 3 days and sacrificed 8 h after the final dose. Result: The SFN dose rate was then increased to 100 mg/kg/day for 3 days to see if higher doses might effectively antagonize rifampicin induction. Again, rifampicin administration led to a large but highly variable (and thus not significant) increase in Cyp3a11 mRNA that was not abrogated by co-administration of SFN. In fact, in these mice, the 100 mg dose of SFN led to an higher levels of cyp3A11 mRNA induction relative to rifampicin alone; i.e., 3.53+/-0.76 to 12.9+/-7.3 fold.
Part Used : ต้นอ่อนActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Sulforaphane (SFN)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age :Route : IntraperitonealDose/Conc.(herb) : 25 mg/kg/, 3 times per dayDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: Loss of righting Reflex (LORR) assay. - For the third arm, mice were dosed with rifampicin (40 mg/kg once per day, at a volume of 5 ml/kg) and SFN (50 mg/kg, 3 times per day via IP at a volume of 5 ml/kg) for a further three days. Result: Consistent with the induction of Cyp3a11 mRNA following rifampicin, mice administered 40 mg/kg/d of rifampicin had a significantly reduced LORR time following a dose of 2,2,2-tribromoethanol. Co-administration of SFN at 25 mg/kg dose had no effect on the ability of rifampicin to induce Cyp3a11, as indicated by LORR times.
Part Used : ต้นอ่อนActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Sulforaphane (SFN)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age :Route : IntraperitonealDose/Conc.(herb) : 50 mg/kg/, 3 times per dayDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: Loss of righting Reflex (LORR) assay. - Mice were dosed with rifampicin (40 mg/kg once per day, at a volume of 5 ml/kg) and SFN (50 mg/kg, 3 times per day via IP at a volume of 5 ml/kg) for a further three days. Result: Consistent with the induction of Cyp3a11 mRNA following rifampicin, mice administered 40 mg/kg/d of rifampicin had a significantly reduced LORR time following a dose of 2,2,2-tribromoethanol. Co-administration of SFN at 50 mg/kg dose had no effect on the ability of rifampicin to induce Cyp3a11, as indicated by LORR times.
