Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 10 mg/kg
Duration : 7 days
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Clozapine
Dose/Conc.(drug) : 100 mg/kg
Remark : Type of experiment: rat medial prefrontal cortex
Note : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.